VaLChrom – validation of chromatographic methods

Publications

Survey

In 2013 we conducted a survey among several Estonian laboratories about using and validating chromatographic methods. The main goal of the survey was to find out the difficulties different laboratories are facing in order to design VaLChrom software in a good way.  The most important difficulties in validating chromatographic methods are concerning uncertainty estimation and data processing. It has also been mentioned that deciding about the validation scope is complicated. The results of the survey show that there is a need for a helping validation software.

Journal papers:

Our most relevant papers are listed below.

1. Anneli Kruve, Riin Rebane, Karin Kipper, Maarja-Liisa Oldekop, Hanno Evard, Koit Herodes, Pekka Ravio, Ivo Leito. Tutorial review on validation of liquid chromatography-mass spectrometry methods, Analytica Chimica Acta, (2015), 870

2. Riin Rebane, Toomas Rodima, Agnes Kütt, Koit Herodes. Development of amino acid derivatization reagents for liquid chromatography electrospray ionization mass spectrometric analysis and ionization efficiency measurements, Journal of Chromatography A, (2015), 1390, 62-70

Master’s theses

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